Drug interaction is typical in the case of Tramadol.All type of people can use this medication.So people who are already undergoing treatment for the disease like blood pressure, cholesterol, sugar patients have to take medicines on a daily basis. If they want to take this then consulting a doctor will help to avoid severe side effects because Tramadol easily interacts with other drugs and it may lead to death. On the other hand, people who are already taking this drug wants to take additional medication for some other purpose like a headache, stomach pain, they also need to check with their doctor because of the cross-interaction of this.So avoid using other drugs while taking this medication.
There’s quite a long list of drugs that interact with Tramadol in the body resulting in several effects. A ‘No’ to these dangerous combinations can prevent severe ill-effects.The most critical drug interaction takes place with painkillers and antidepressants. So keep this in mind while taking the medication.
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Interactions of Tramadol with other painkillers
It works by interacting with the central nervous system. But there are many non-narcotic drugs too such as paracetamol that can relieve pain, and if these drugs are taken along with Tramadol, the effect would be a stronger alleviation of suffering. Such combinations are recommended for treatment of some medical conditions but should be taken only after consultation with health care provider.
Tramadol interactions with anti-depressants
A Certain class of antidepressants such as monoamine oxidase (MAO) inhibitors such as Aurorix and Marplan or Selective serotonin reuptake inhibitors (SSRIs) such as Lexapro and Prozac interact with Tramadol when taken together and can cause severely combined effects to the extent of death too.
Tramadol’s interaction with MAO has been known to cause agitation, headache, fluctuations in blood pressure, coma and even death. In fact, the communications can be so intense that it is recommended to keep a gap of at least two weeks between quitting Tramadol and initiating MAO’s consumption. On the other hand, SSRIs interactions increase risk of seizures to many folds and might even lead to the development of serotonin syndrome.
Other centrally acting drugs such as anti-anxiety medications or sleeping pills may increase the downsides of Tramadol that includes sedative effect and increased risk of seizures or respiratory disorders.
What are the other drugs interacts with Tramadol?
A survey says that nearly 759 drugs interact with this medication.The interaction is categorised into three categories like 443 significant drugs, 312 moderate drugs and four minor drugs interact with this.
Drugs like Carbamazepine that are used for the treatment of epilepsy, if taken along with Tramadol increases the metabolism of the later thereby decreasing the seizure threshold which is the most problematic symptom of epilepsy. Therefore, the use of this combination of drug is highly discouraged as one alters the effect of another.
Apart from this class, certain antifungal drugs like Orungal, Nizoral and antibiotics like erythromycin that works by inhibiting the action of an enzyme CYP3A4 also interfere with Tramadol mechanism and is known to cause ill-effects on health.
The list does not end with this. A lot many heart-rhythm medications (ex: Amiodarone), blood pressure medications (ex: Diltiazem), HIV-AIDS drugs and cancer medications (ex: Gleevec) have also been reported to interact with Tramadol.
Although many studies have successfully reported how tramadol interact with other drugs, a lot much is still unknown to consumers. Not only drugs, but alcohol, nicotine and even food supplements do interact with the drug in the body. And therefore it is highly recommended to inform the physician regarding dietary intake, food supplements and all the drugs well on time before he prescribes any medication so that the best advice can be given after complete analysis of the patient’s body’s profile.